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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50254531
Substrate
n/a
Meas. Tech.
ChEMBL_558763 (CHEMBL1019892)
IC50
140±n/a nM
Citation
 Porter, J; Payne, A; de Candole, B; Ford, D; Hutchinson, B; Trevitt, G; Turner, J; Edwards, C; Watkins, C; Whitcombe, I; Davis, J; Stubberfield, C Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors. Bioorg Med Chem Lett 19:230-3 (2008) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50254531
Synonyms:
5-methyl-1-(2-((S)-3-((methylamino)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)-N,N-diphenyl-1H-pyrazole-3-carboxamide | CHEMBL500866
Type:
Small organic molecule
Emp. Form.:
C35H33N5O2
Mol. Mass.:
555.6688
SMILES:
CNC[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1nc(cc1C)C(=O)N(c1ccccc1)c1ccccc1 |r|
Structure:
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