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Target
Bcl2-associated agonist of cell death
Ligand
BDBM50254529
Substrate
n/a
Meas. Tech.
ChEMBL_558764 (CHEMBL1019893)
IC50
5170±n/a nM
Citation
 Porter, J; Payne, A; de Candole, B; Ford, D; Hutchinson, B; Trevitt, G; Turner, J; Edwards, C; Watkins, C; Whitcombe, I; Davis, J; Stubberfield, C Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors. Bioorg Med Chem Lett 19:230-3 (2008) [PubMed]  Article 
Target
Name:
Bcl2-associated agonist of cell death
Synonyms:
BAD | BAD_HUMAN | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-XL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-antagonist of cell death (BAD)
Type:
PROTEIN
Mol. Mass.:
18393.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_478760
Residue:
168
Sequence:
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
  
Inhibitor
Name:
BDBM50254529
Synonyms:
CHEMBL453466 | methyl 2-((S)-2-(2-(3-(diphenylcarbamoyl)-5-methyl-1H-pyrazol-1-yl)benzoyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)acetate
Type:
Small organic molecule
Emp. Form.:
C36H32N4O4
Mol. Mass.:
584.6637
SMILES:
COC(=O)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccccc1-n1nc(cc1C)C(=O)N(c1ccccc1)c1ccccc1 |r|
Structure:
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