Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50255199
Substrate
n/a
Meas. Tech.
ChEMBL_515983 (CHEMBL981472)
IC50
11±n/a nM
Citation
 LoVerme, J; Duranti, A; Tontini, A; Spadoni, G; Mor, M; Rivara, S; Stella, N; Xu, C; Tarzia, G; Piomelli, D Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. Bioorg Med Chem Lett 19:639-43 (2009) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50255199
Synonyms:
1-(4-Chloro-benzyl)-2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid adamantan-2-ylamide | CHEMBL482221
Type:
Small organic molecule
Emp. Form.:
C29H31ClN2O
Mol. Mass.:
459.022
SMILES:
Cc1c(cc(-c2ccccc2)n1Cc1ccc(Cl)cc1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:32:31:29:25.26.27,THB:32:26:23.31.30:29,27:26:23:30.28.29,27:28:23:25.32.26,22:23:25.32.26:30.28.29,(19.05,-.61,;17.56,-.21,;17.02,1.23,;15.48,1.16,;15.08,-.33,;13.64,-.87,;12.45,.11,;11.01,-.44,;10.76,-1.96,;11.96,-2.93,;13.4,-2.38,;16.36,-1.17,;16.44,-2.71,;17.81,-3.41,;17.88,-4.95,;19.25,-5.65,;20.54,-4.82,;21.91,-5.52,;20.46,-3.27,;19.09,-2.58,;17.84,2.53,;17.13,3.9,;19.38,2.47,;20.38,3.64,;21.57,4.92,;22.9,4.44,;24.3,4.79,;24.3,6.32,;22.9,6.89,;21.56,6.41,;21.87,5.66,;21.88,4.07,;23.29,3.51,)|
Structure:
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