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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50276689
Substrate
n/a
Meas. Tech.
ChEMBL_541154 (CHEMBL1030715)
Kd
>1000000±n/a nM
Citation
 Lee, JY; Jeong, KW; Lee, JU; Kang, DI; Kim, Y Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics. Bioorg Med Chem 17:1506-13 (2009) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50276689
Synonyms:
7-(allylthio)-3-methyl-6,7-dihydro-4H-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one | CHEMBL459370
Type:
Small organic molecule
Emp. Form.:
C8H10N4OS2
Mol. Mass.:
242.321
SMILES:
Cc1nnc2SC(Nn2c1=O)SCC=C
Structure:
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