Reaction Details Report a problem with these data
Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50276687
Substrate
n/a
Meas. Tech.
ChEMBL_541154 (CHEMBL1030715)
Kd
1220±n/a nM
Citation
 Lee, JY; Jeong, KW; Lee, JU; Kang, DI; Kim, Y Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics. Bioorg Med Chem 17:1506-13 (2009) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50276687
Synonyms:
3-(1-(3,4-dihydroxyphenyl)-1-oxopropan-2-yl)-6,7-dimethoxyisobenzofuran-1(3H)-one | CHEMBL459369
Type:
Small organic molecule
Emp. Form.:
C19H18O7
Mol. Mass.:
358.342
SMILES:
COc1ccc2C(OC(=O)c2c1OC)C(C)C(=O)c1ccc(O)c(O)c1
Structure:
Search PDB for entries with ligand similarity: