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Target
Stearoyl-CoA desaturase
Ligand
BDBM50258196
Substrate
n/a
Meas. Tech.
ChEMBL_562452 (CHEMBL1010955)
IC50
9.6±n/a nM
Citation
 Koltun, DO; Parkhill, EQ; Vasilevich, NI; Glushkov, AI; Zilbershtein, TM; Ivanov, AV; Cole, AG; Henderson, I; Zautke, NA; Brunn, SA; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett 19:2048-52 (2009) [PubMed]  Article 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Homo sapiens (Human)
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM50258196
Synonyms:
3-(7-oxo-6-p-tolyl-2-(3-(trifluoromethyl)benzylamino)pteridin-8(7H)-yl)propanamide | CHEMBL495352
Type:
Small organic molecule
Emp. Form.:
C24H21F3N6O2
Mol. Mass.:
482.4577
SMILES:
Cc1ccc(cc1)-c1nc2cnc(NCc3cccc(c3)C(F)(F)F)nc2n(CCC(N)=O)c1=O
Structure:
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