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Target
Acyl-CoA 6-desaturase
Ligand
BDBM50257919
Substrate
n/a
Meas. Tech.
ChEMBL_562450 (CHEMBL1010953)
IC50
>30±n/a nM
Citation
 Koltun, DO; Parkhill, EQ; Vasilevich, NI; Glushkov, AI; Zilbershtein, TM; Ivanov, AV; Cole, AG; Henderson, I; Zautke, NA; Brunn, SA; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett 19:2048-52 (2009) [PubMed]  Article 
Target
Name:
Acyl-CoA 6-desaturase
Synonyms:
FADS2_RAT | Fads2 | Fadsd6 | Fatty acid desaturase 2
Type:
PROTEIN
Mol. Mass.:
52399.93
Organism:
Rattus norvegicus
Description:
ChEMBL_852950
Residue:
444
Sequence:
MGKGGNQGEGSTELQAPMPTFRWEEIQKHNLRTDRWLVIDRKVYNVTKWSQRHPGGHRVIGHYSGEDATDAFRAFHLDLDFVGKFLKPLLIGELAPEEPSLDRGKSSQITEDFRALKKTAEDMNLFKTNHLFFFLLLSHIIVMESIAWFILSYFGNGWIPTVITAFVLATSQAQAGWLQHDYGHLSVYKKSIWNHIVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDIKSLHVFVLGEWQPLEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIRRRDWVDLAWAISYYARFFYTYIPFYGILGALVFLNFIRFLESHWFVWVTQMNHIVMEIDLDHYRDWFSSQLAATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIVSSLKKSGELWLDAYLHK
  
Inhibitor
Name:
BDBM50257919
Synonyms:
CHEMBL493960 | N-(2-(7-(3,4-dichlorobenzylamino)-3-(4-methoxyphenyl)-2-oxoquinoxalin-1(2H)-yl)ethyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C26H24Cl2N4O3
Mol. Mass.:
511.4
SMILES:
COc1ccc(cc1)-c1nc2ccc(NCc3ccc(Cl)c(Cl)c3)cc2n(CCNC(C)=O)c1=O
Structure:
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