Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM50279107
Substrate
n/a
Meas. Tech.
ChEMBL_545452 (CHEMBL1032475)
IC50
5000±n/a nM
Citation
 Pegoraro, S; Lang, M; Dreker, T; Kraus, J; Hamm, S; Meere, C; Feurle, J; Tasler, S; Prütting, S; Kuras, Z; Visan, V; Grissmer, S Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett 19:2299-304 (2009) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM50279107
Synonyms:
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | CHEMBL498270
Type:
Small organic molecule
Emp. Form.:
C22H17ClN2
Mol. Mass.:
344.837
SMILES:
Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1
Structure:
Search PDB for entries with ligand similarity: