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Target
Peptidyl-prolyl cis-trans isomerase A
Ligand
BDBM50267549
Substrate
n/a
Meas. Tech.
ChEMBL_563422 (CHEMBL960174)
Kd
200500±n/a nM
Citation
 Li, J; Tan, Z; Tang, S; Hewlett, I; Pang, R; He, M; He, S; Tian, B; Chen, K; Yang, M Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid. Bioorg Med Chem 17:3177-88 (2009) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase A
Synonyms:
CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIA_HUMAN | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Rotamase A
Type:
Protein
Mol. Mass.:
18015.32
Organism:
Homo sapiens (Human)
Description:
P62937
Residue:
165
Sequence:
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
  
Inhibitor
Name:
BDBM50267549
Synonyms:
1-(3-Bromophenyl)-3-(2-(2-(diethylamino)-6-methylpyrimidin-4-ylamino)ethyl)thiourea | CHEMBL482840
Type:
Small organic molecule
Emp. Form.:
C18H25BrN6S
Mol. Mass.:
437.4
SMILES:
CCN(CC)c1nc(C)cc(NCCNC(=S)Nc2cccc(Br)c2)n1
Structure:
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