Reaction Details Report a problem with these data
Target
Caspase-6
Ligand
BDBM50258699
Substrate
n/a
Meas. Tech.
ChEMBL_523092 (CHEMBL1006644)
IC50
>500000±n/a nM
Citation
 Podichetty, AK; Wagner, S; Schröer, S; Faust, A; Schäfers, M; Schober, O; Kopka, K; Haufe, G Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis. J Med Chem 52:3484-95 (2009) [PubMed]  Article 
Target
Name:
Caspase-6
Synonyms:
Apoptotic protease Mch-2 | CASP-6 | CASP6 | CASP6_HUMAN | Caspase | MCH2
Type:
Enzyme
Mol. Mass.:
33312.62
Organism:
Homo sapiens (Human)
Description:
P55212
Residue:
293
Sequence:
MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
  
Inhibitor
Name:
BDBM50258699
Synonyms:
(S)-1-[(S)-2,3-Dihydroxypropyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin | CHEMBL511723
Type:
Small organic molecule
Emp. Form.:
C17H22N2O7S
Mol. Mass.:
398.431
SMILES:
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2N(C[C@H](O)CO)C(=O)C(=O)c2c1 |r|
Structure:
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