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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50279898
Substrate
n/a
Meas. Tech.
ChEBML_210745
IC50
1318000±n/a nM
Citation
 Cushman, M; Nagarathnam, D; Gopal, D; Geahlen, RL Synthesis and evaluation of new protein-tyrosine kinase inhibitors. Part 2. Phenylhydrazones. Bioorg Med Chem Lett 1:215-218 (1991)    Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50279898
Synonyms:
CHEMBL62881 | N-Phenyl-N'-[1-pyridin-3-yl-meth-(E)-ylidene]-hydrazine
Type:
Small organic molecule
Emp. Form.:
C12H11N3
Mol. Mass.:
197.2358
SMILES:
C(N=Nc1ccccc1)c1cccnc1 |w:2.2|
Structure:
Search PDB for entries with ligand similarity: