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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50280605
Substrate
n/a
Meas. Tech.
ChEBML_138806
IC50
50±n/a nM
Citation
 Wermuth, CG; Bourguignon, JJ; Hoffmann, R; Boigegrain, R; Brodin, R; Kan, JP; Soubrié, P SR 46559 A and related aminopyridazines are potent muscarinic agonists with no cholinergic syndrome Bioorg Med Chem Lett 2:833-838 (1992)    Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50280605
Synonyms:
CHEMBL353869 | N*2*,N*2*-Diethyl-2-methyl-N*1*-(5-phenyl-6-propyl-pyridazin-3-yl)-propane-1,2-diamine
Type:
Small organic molecule
Emp. Form.:
C21H32N4
Mol. Mass.:
340.5056
SMILES:
CCCc1nnc(NCC(C)(C)N(CC)CC)cc1-c1ccccc1
Structure:
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