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Target
Thymidine kinase, cytosolic
Ligand
BDBM50282061
Substrate
n/a
Meas. Tech.
ChEMBL_208018 (CHEMBL814147)
IC50
3000±n/a nM
Citation
 Kim, CU; Misco, PF; Luh, BY; Terry, B; Bisacchi, G; Mansuri, MM (2R, 4S, 5S)-1-(tetrahydro-4-hydroxy-5-methoxy-2-furanyl)thymine: a potent selective inhibitor of herpes simplex thymidine kinase Bioorg Med Chem Lett 3:1571-1576 (1993)    Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_HUMAN | TK1
Type:
PROTEIN
Mol. Mass.:
25476.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333884
Residue:
234
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
  
Inhibitor
Name:
BDBM50282061
Synonyms:
1-((2R,4S,5R)-5-Ethynyl-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | CHEMBL289100
Type:
Small organic molecule
Emp. Form.:
C11H12N2O4
Mol. Mass.:
236.224
SMILES:
Cc1cn([C@H]2C[C@H](O)[C@H](O2)C#C)c(=O)[nH]c1=O
Structure:
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