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Target
Type-1 angiotensin II receptor
Ligand
BDBM50282218
Substrate
n/a
Meas. Tech.
ChEMBL_36159 (CHEMBL646971)
EC50
600±n/a nM
Citation
 Bantick, JR; Beaton, HG; Cooper, SL; Hill, S; Hirst, SC; McInally, T; Spencer, J; Tinker, AC; Willis, PA New non-peptide angiotensin II receptor antagonists. 2: structure - activity relationship of a series of annelated 2(1H)-pyridinones Bioorg Med Chem Lett 4:127-132 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_BOVIN | Angiotensin II type 1a (AT-1a) receptor
Type:
PROTEIN
Mol. Mass.:
41107.81
Organism:
Bos taurus
Description:
ChEMBL_36779
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCIEVE
  
Inhibitor
Name:
BDBM50282218
Synonyms:
4-Hydroxy-7-methylsulfanyl-3-phenyl-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-quinolin-2-one | CHEMBL282082
Type:
Small organic molecule
Emp. Form.:
C30H23N5O2S
Mol. Mass.:
517.601
SMILES:
CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2c1
Structure:
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