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Target
Type-1 angiotensin II receptor B
Ligand
BDBM50282258
Substrate
n/a
Meas. Tech.
ChEMBL_34825 (CHEMBL648759)
IC50
71±n/a nM
Citation
 Bernhart, CA; Hundricourt, FB; Assens, JL; Gougat, J; Lacour, C; Roccon, A; Cazaubon, C; Brelière, JC; Fur, GL; Nisato, D Cyclopentanespiro-3H-dihydro-pyrimidinones as Angiotensin II AT1 receptor antagonists Bioorg Med Chem Lett 4:157-162 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50282258
Synonyms:
4'-(8-Butyl-6-oxo-7,9-diaza-spiro[4.5]dec-8-en-7-ylmethyl)-biphenyl-2-carboxylic acid | CHEMBL295646
Type:
Small organic molecule
Emp. Form.:
C26H30N2O3
Mol. Mass.:
418.528
SMILES:
CCCCC1=NCC2(CCCC2)C(=O)N1Cc1ccc(cc1)-c1ccccc1C(O)=O |t:4|
Structure:
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