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Target
Type-1 angiotensin II receptor
Ligand
BDBM50282378
Substrate
n/a
Meas. Tech.
ChEMBL_36168 (CHEMBL646980)
IC50
1200±n/a nM
Citation
 Cho, N; Kubo, K; Furuya, S; Sugiura, Y; Yasuma, T; Kohara, Y; Ojima, M; Inada, Y; Nishikawa, K; Naka, T A new class of diacidic nonpeptide angiotensin II receptor antagonists Bioorg Med Chem Lett 4:35-40 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_BOVIN | Angiotensin II type 1a (AT-1a) receptor
Type:
PROTEIN
Mol. Mass.:
41107.81
Organism:
Bos taurus
Description:
ChEMBL_36779
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCIEVE
  
Inhibitor
Name:
BDBM50282378
Synonyms:
2-Ethylsulfanyl-4-methyl-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-thieno[3,4-d]imidazole | CHEMBL436192
Type:
Small organic molecule
Emp. Form.:
C22H20N6S2
Mol. Mass.:
432.564
SMILES:
CCSc1nc2c(C)scc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Structure:
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