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Target
Type-1 angiotensin II receptor
Ligand
BDBM50282818
Substrate
n/a
Meas. Tech.
ChEBML_36169
IC50
39±n/a nM
Citation
 Levin, JI; Chan, PS; Coupet, J; Bailey, TK; Vice, G; Thibault, L; F., L; Venkatesan, AM; Cobuzzi, A 6-isoxazolinyl and isoxazolidinyl substituted quinazolinones as angiotensin II receptor antagonists Bioorg Med Chem Lett 4:1703-1708 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_BOVIN | Angiotensin II type 1a (AT-1a) receptor
Type:
PROTEIN
Mol. Mass.:
41107.81
Organism:
Bos taurus
Description:
ChEMBL_36779
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCIEVE
  
Inhibitor
Name:
BDBM50282818
Synonyms:
2-Butyl-6-((2S,3aR)-6,6-dimethyl-hexahydro-pyrrolo[1,2-b]isoxazol-2-yl)-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-quinazolin-4-one | CHEMBL44798
Type:
Small organic molecule
Emp. Form.:
C34H37N7O2
Mol. Mass.:
575.7033
SMILES:
CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@@H]1C[C@H]2CCC(C)(C)N2O1
Structure:
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