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Target
Neutrophil elastase
Ligand
BDBM50282872
Substrate
n/a
Meas. Tech.
ChEBML_64002
Ki
32±n/a nM
Citation
 Hlasta, DJ; Bell, MR; Boaz, NW; Court, JJ; Desai, RC; Franke, CA; Mura, AJ; Subramanyam, C; Dunlap, RP A benzisothiazolone class of potent, selective mechanism-based inhibitors of human leukocyte elastase Bioorg Med Chem Lett 4:1801-1806 (1994)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50282872
Synonyms:
2-(1-Cyclohexyl-1H-tetrazol-5-ylsulfanylmethyl)-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL53523
Type:
Small organic molecule
Emp. Form.:
C15H17N5O3S2
Mol. Mass.:
379.457
SMILES:
O=C1N(CSc2nnnn2C2CCCCC2)S(=O)(=O)c2ccccc12
Structure:
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