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Target
Type-1 angiotensin II receptor B
Ligand
BDBM50283551
Substrate
n/a
Meas. Tech.
ChEMBL_36638 (CHEMBL652349)
IC50
15±n/a nM
Citation
 Huang, HC; Chamberlain, TS; Olins, GM; Corpus, VM; Chen, ST; McMahon, EG; Palomo, MA; Blaine, EH; Manning, RE Discovery of nonpeptide potent conformationally restricted angiotensin II receptor antagonists Bioorg Med Chem Lett 4:2591-2596 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50283551
Synonyms:
1-{(5S,8S)-3-Butyl-5-[2'-(2H-tetrazol-5-yl)-biphenyl-4-yl]-5,6,7,8-tetrahydro-imidazo[1,5-a]pyridin-8-yl}-pyrrolidine-2,5-dione | CHEMBL316392
Type:
Small organic molecule
Emp. Form.:
C28H29N7O2
Mol. Mass.:
495.5756
SMILES:
CCCCc1ncc2[C@H](CC[C@@H](c3ccc(cc3)-c3ccccc3-c3nnn[nH]3)n12)N1C(=O)CCC1=O
Structure:
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