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Target
Mu-type opioid receptor
Ligand
BDBM50450288
Substrate
n/a
Meas. Tech.
ChEBML_138878
EC50
1700±n/a nM
Citation
 Sagara, T; Okamura, M; Shimohigashi, Y; Ohno, M; Kanematsu, K Specific affinity labeling of μ opioid receptors in rat brain by S-activated sulfhydryldihydromorphine analogs Bioorg Med Chem Lett 5:1609-1614 (1995)    Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50450288
Synonyms:
CHEMBL2112189
Type:
Small organic molecule
Emp. Form.:
C22H23N3O5S2
Mol. Mass.:
473.565
SMILES:
[H][C@]12Oc3c4c(C[C@]5([H])C([C@H](C[C@@H]1O)SSc1ccc(cn1)[N+]([O-])=O)[C@]24CCN5C)ccc3O |TLB:29:28:9:4.5.6|
Structure:
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