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Target
Stromelysin-1
Ligand
BDBM50284909
Substrate
n/a
Meas. Tech.
ChEBML_205494
IC50
600±n/a nM
Citation
 Yeh, LA; Chen, J; Baculi, F; Gingrich, DE; Shen, TY Inhibition of metalloproteinase by futoenone derivatives Bioorg Med Chem Lett 5:1637-1642 (1995)    Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50284909
Synonyms:
(R)-3-Benzo[1,3]dioxol-5-yl-4-((S)-6-mercapto-5-methoxy-2,3-dihydro-benzofuran-2-yl)-butan-2-ol | CHEMBL295767
Type:
Small organic molecule
Emp. Form.:
C20H22O5S
Mol. Mass.:
374.451
SMILES:
COc1cc2C[C@H](C[C@@H](C(C)O)c3ccc4OCOc4c3)Oc2cc1S
Structure:
Search PDB for entries with ligand similarity: