Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50284979
Substrate
n/a
Meas. Tech.
ChEBML_28195
IC50
20±n/a nM
Citation
 Kumazawa, T; Harakawa, H; Fukui, H; Shirakura, S; Ohishi, E; Yamada, K N-(1-phenyl-2-benzimidazolyl)-N′-phenylurea derivatives as potent in hibitors of acylcoa:cholesterol acyltransferase (ACAT) Bioorg Med Chem Lett 5:1829-1832 (1995)    Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50284979
Synonyms:
1-[1-(3-Chloro-phenyl)-1H-benzoimidazol-2-yl]-3-(2,6-diisopropyl-phenyl)-urea | CHEMBL416485
Type:
Small organic molecule
Emp. Form.:
C26H27ClN4O
Mol. Mass.:
446.972
SMILES:
CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1cccc(Cl)c1
Structure:
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