Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50284965
Substrate
n/a
Meas. Tech.
ChEBML_28195
IC50
33±n/a nM
Citation
 Kumazawa, T; Harakawa, H; Fukui, H; Shirakura, S; Ohishi, E; Yamada, K N-(1-phenyl-2-benzimidazolyl)-N′-phenylurea derivatives as potent in hibitors of acylcoa:cholesterol acyltransferase (ACAT) Bioorg Med Chem Lett 5:1829-1832 (1995)    Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50284965
Synonyms:
1-[3-(2-Chloro-phenyl)-3H-imidazo[4,5-b]pyridin-2-yl]-3-(2,6-diisopropyl-phenyl)-urea | CHEMBL55870
Type:
Small organic molecule
Emp. Form.:
C25H26ClN5O
Mol. Mass.:
447.96
SMILES:
CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2cccnc2n1-c1ccccc1Cl |(20.07,-7.3,;18.53,-7.31,;17.78,-8.64,;17.76,-5.98,;18.53,-4.64,;17.76,-3.31,;16.2,-3.32,;15.45,-4.67,;13.91,-4.67,;13.12,-3.34,;12.42,-5.07,;16.22,-5.98,;15.47,-7.33,;13.93,-7.33,;13.14,-6,;13.17,-8.66,;11.63,-8.68,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,;10.72,-9.92,;10.72,-11.46,;12.02,-12.23,;12.02,-13.77,;10.69,-14.54,;9.36,-13.75,;9.36,-12.23,;7.82,-12.23,)|
Structure:
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