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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50285220
Substrate
n/a
Meas. Tech.
ChEBML_51690
IC50
5400±n/a nM
Citation
 Leblanc, Y; Gauthier, J; Ethier, D; Guay, J; Mancini, J; Riendeau, D; Tagari, P; Vickers, P; Wong, E; Prasit, P Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 and Cox-1 inhibitors Bioorg Med Chem Lett 5:2123-2128 (1995)    Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Enzyme
Mol. Mass.:
68692.62
Organism:
Homo sapiens (Human)
Description:
P23219
Residue:
599
Sequence:
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
  
Inhibitor
Name:
BDBM50285220
Synonyms:
4-[2-(4-Fluoro-phenyl)-5-(1-hydroxy-1-methyl-ethyl)-thiophen-3-yl]-benzenesulfonamide | CHEMBL308682
Type:
Small organic molecule
Emp. Form.:
C19H18FNO3S2
Mol. Mass.:
391.48
SMILES:
CC(C)(O)c1cc(c(s1)-c1ccc(F)cc1)-c1ccc(cc1)S(N)(=O)=O
Structure:
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