Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50285752
Substrate
n/a
Meas. Tech.
ChEBML_35430
IC50
1.1±n/a nM
Citation
 Deprez, P; Guillaume, J; Corbier, A; Fortin, M; Vevert, JP; Heckmann, B Balanced AT1 and AT2 angiotensin II antagonists. II. Potent 5 α-hydroxyacid imidazolyl biphenyl sulfonylureas Bioorg Med Chem Lett 5:2611-2616 (1995)    Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50285752
Synonyms:
5-alpha-hydroxyacid imidazolyl biphenyl sulfonyl urea analogue | CHEMBL314506
Type:
Small organic molecule
Emp. Form.:
C36H44N4O6S2
Mol. Mass.:
692.888
SMILES:
CCCCCCC(O)(C(O)=O)c1c(SC)nc(CCC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: