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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50286051
Substrate
n/a
Meas. Tech.
ChEBML_158918
IC50
900±n/a nM
Citation
 Bertenshaw, SR; Talley, JJ; Rogier, DJ; Graneto, MJ; Rogers, RS; Kramer, SW; Penning, TD; Koboldt, CM; Veenhuizen, AW; Zhang, Y; Perkins, WE 3,4-diarylthiophenes are selective COX-2 inhibitors Bioorg Med Chem Lett 5:2919-2922 (1995)    Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Enzyme
Mol. Mass.:
68692.62
Organism:
Homo sapiens (Human)
Description:
P23219
Residue:
599
Sequence:
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
  
Inhibitor
Name:
BDBM50286051
Synonyms:
3-(4-Methanesulfonyl-phenyl)-4-(4-methoxy-phenyl)-thiophene | CHEMBL98903
Type:
Small organic molecule
Emp. Form.:
C18H16O3S2
Mol. Mass.:
344.448
SMILES:
COc1ccc(cc1)-c1cscc1-c1ccc(cc1)S(C)(=O)=O
Structure:
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