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Target
Interstitial collagenase
Ligand
BDBM50286129
Substrate
n/a
Meas. Tech.
ChEBML_101746
IC50
220±n/a nM
Citation
 Hughes, I; Harper, GP; Karran, EH; Markwell, RE; Miles-Williams, AJ Synthesis of thiophenol derivatives as inhibitors of human collagenase Bioorg Med Chem Lett 5:3039-3042 (1995)    Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50286129
Synonyms:
(R)-2-(2-Mercapto-3-methoxy-benzyl)-4-methyl-pentanoic acid [(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethyl]-amide | CHEMBL102499
Type:
Small organic molecule
Emp. Form.:
C25H34N2O4S
Mol. Mass.:
458.613
SMILES:
CNC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@H](CC(C)C)Cc1cccc(OC)c1S
Structure:
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