Reaction Details
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Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50287078
Substrate
n/a
Meas. Tech.
ChEBML_154714
IC50
5000±n/a nM
Citation
Shahripour, A; Plummer, MS; Lunney, EA; Para, KS; Stankovic, CJ; Rubin, JR; Humblet, C; Fergus, JH; Marks, JS; Herrera, R; Hubbell, SE; Saltiel, AR; Sawyer, TK Novel phosphotyrosine mimetics in the design of peptide ligands for pp60src SH2 domain Bioorg Med Chem Lett 6:1209-1214 (1996) Article More Info.:
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Inhibitor
Name:
BDBM50287078
Synonyms:
(S)-2-[(2S,3S)-2-(4-Carboxy-2-{4-carboxy-2-[(Z)-2-carboxy-3-(4-phosphonooxy-phenyl)-acryloylamino]-butyrylamino}-butyrylamino)-3-methyl-pentanoylamino]-pentanedioic acid | CHEMBL280161 | CHEMBL3143155
Type:
Small organic molecule
Emp. Form.:
C31H41N4O18P
Mol. Mass.:
788.647
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)C(=C\c1ccc(OP(O)(O)=O)cc1)\C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Structure:
