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Target
Endothelin-1 receptor
Ligand
BDBM50288263
Substrate
n/a
Meas. Tech.
ChEBML_65477
IC50
100±n/a nM
Citation
 Raju, B; Wu, C; Kois, A; Verner, E; Okun, I; Stavros, F; Chan, MF Thiophenesulfonamides as endothelin receptor antagonists Bioorg Med Chem Lett 6:2651-2656 (1996)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50288263
Synonyms:
3-(2,4-Dimethyl-phenyl)-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide | CHEMBL89688
Type:
Small organic molecule
Emp. Form.:
C16H15BrN2O3S2
Mol. Mass.:
427.336
SMILES:
Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(C)cc2C)c1Br
Structure:
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