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Target
Peptidyl-glycine alpha-amidating monooxygenase
Ligand
BDBM50288771
Substrate
n/a
Meas. Tech.
ChEBML_152798
Ki
0.100000±n/a nM
Citation
 Casara, P; Ganzhorn, A; Philippo, C; Chanal, MC; Danzin, C Unsaturated thioacetic acids as novel mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase Bioorg Med Chem Lett 6:393-396 (1996)    Article 
Target
Name:
Peptidyl-glycine alpha-amidating monooxygenase
Synonyms:
AMD_HUMAN | PAL | PAM | PHM | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase | Peptidylamidoglycolate lyase | Peptidylglycine alpha-hydroxylating monooxygenase
Type:
PROTEIN
Mol. Mass.:
108328.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_885021
Residue:
973
Sequence:
MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALDIRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESESDLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMENKPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEHKLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEEYSAPLPALAPSSS
  
Inhibitor
Name:
BDBM50288771
Synonyms:
((E)-Styrylsulfanyl)-acetic acid | CHEMBL127222
Type:
Small organic molecule
Emp. Form.:
C10H10O2S
Mol. Mass.:
194.25
SMILES:
OC(=O)CS\C=C\c1ccccc1
Structure:
Search PDB for entries with ligand similarity: