Reaction Details Report a problem with these data
Target
Squalene monooxygenase
Ligand
BDBM50288841
Substrate
n/a
Meas. Tech.
ChEBML_201931
IC50
100±n/a nM
Citation
 Gotteland, JP; Delhon, A; Junquéro, D; Oms, P; Halazy, S Design and synthesis of new hypocholesterolemic organosilanes with antioxidant properties Bioorg Med Chem Lett 6:533-538 (1996)    Article 
Target
Name:
Squalene monooxygenase
Synonyms:
ERG1 | ERG1_HUMAN | SE | SQLE | Squalene epoxidase
Type:
PROTEIN
Mol. Mass.:
63936.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_201924
Residue:
574
Sequence:
MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSGSQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
  
Inhibitor
Name:
BDBM50288841
Synonyms:
(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenyl)-[(dimethyl-o-tolyl-silanyl)-methyl]-amine | CHEMBL434507
Type:
Small organic molecule
Emp. Form.:
C28H40N2Si
Mol. Mass.:
432.7161
SMILES:
CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(NC[Si](C)(C)c2ccccc2C)c1
Structure:
Search PDB for entries with ligand similarity: