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Target
Type-2 angiotensin II receptor
Ligand
BDBM50282471
Substrate
n/a
Meas. Tech.
ChEBML_35284
IC50
16±n/a nM
Citation
 de Laszlo, SE; Glinka, TW; Greenlee, WJ; Ball, R; Nachbar, RB; Prendergast, K The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists Bioorg Med Chem Lett 6:923-928 (1996)    Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50282471
Synonyms:
CHEMBL168771 | N-[3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl]-benzamide
Type:
Small organic molecule
Emp. Form.:
C38H32N4O5S
Mol. Mass.:
656.749
SMILES:
CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Structure:
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