Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50289718
Substrate
n/a
Meas. Tech.
ChEBML_105348
IC50
600±n/a nM
Citation
 Yamada, Y; Ando, K; Komiyama, K; Shibata, S; Nakamura, I; Hayashi, Y; Ikegami, K; Uchida, I Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosets Bioorg Med Chem Lett 7:1863-1868 (1997)    Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50289718
Synonyms:
5-Hydroxy-1H-indole-2-carboxylic acid [(S)-1-((1S,2S,4S)-1-cyclohexylmethyl-2,4-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-amide | CHEMBL56334
Type:
Small organic molecule
Emp. Form.:
C29H41N5O5
Mol. Mass.:
539.6663
SMILES:
CC(C)[C@@H](O)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1cc2cc(O)ccc2[nH]1
Structure:
Search PDB for entries with ligand similarity: