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Target
Endothelin-1 receptor
Ligand
BDBM50290939
Substrate
n/a
Meas. Tech.
ChEBML_63345
IC50
230±n/a nM
Citation
 Dorsch, D; Mederski, WW; Osswald, M; Devant, RM; Schmitges, CJ; Christadler, M; Wilm, C Pyridazinones with a pendant acylsulfonamide moiety as endothelin receptor antagonists Bioorg Med Chem Lett 7:275-280 (1997)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50290939
Synonyms:
CHEMBL97595 | N-[2-Benzo[1,3]dioxol-5-yl-2-(3-methyl-6-oxo-6H-pyridazin-1-yl)-acetyl]-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C20H17N3O6S
Mol. Mass.:
427.43
SMILES:
Cc1ccc(=O)n(n1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccc2OCOc2c1
Structure:
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