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Target
Squalene monooxygenase
Ligand
BDBM50291660
Substrate
n/a
Meas. Tech.
ChEBML_201933
IC50
100±n/a nM
Citation
 Gotteland, JP; Dax, C; Halazy, S Design and synthesis of new potential photoaffinity labels for mammalian squalene epoxidase Bioorg Med Chem Lett 7:1153-1156 (1997)    Article 
Target
Name:
Squalene monooxygenase
Synonyms:
ERG1 | ERG1_HUMAN | SE | SQLE | Squalene epoxidase
Type:
PROTEIN
Mol. Mass.:
63936.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_201924
Residue:
574
Sequence:
MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSGSQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
  
Inhibitor
Name:
BDBM50291660
Synonyms:
CHEMBL16178 | [3-([3,3']Bithiophenyl-5-ylmethoxy)-benzyl]-ethyl-(3-phenyl-prop-2-ynyl)-amine
Type:
Small organic molecule
Emp. Form.:
C27H25NOS2
Mol. Mass.:
443.624
SMILES:
CCN(CC#Cc1ccccc1)Cc1cccc(OCc2cc(cs2)-c2ccsc2)c1
Structure:
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