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Target
Squalene monooxygenase
Ligand
BDBM50032836
Substrate
n/a
Meas. Tech.
ChEBML_201933
IC50
20±n/a nM
Citation
 Gotteland, JP; Dax, C; Halazy, S Design and synthesis of new potential photoaffinity labels for mammalian squalene epoxidase Bioorg Med Chem Lett 7:1153-1156 (1997)    Article 
Target
Name:
Squalene monooxygenase
Synonyms:
ERG1 | ERG1_HUMAN | SE | SQLE | Squalene epoxidase
Type:
PROTEIN
Mol. Mass.:
63936.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_201924
Residue:
574
Sequence:
MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSGSQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
  
Inhibitor
Name:
BDBM50032836
Synonyms:
4-[(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxymethyl)-dimethyl-silanyl]-benzonitrile | 4-[(3-{[(6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxymethyl)-dimethyl-silanyl]-benzonitrile | CHEMBL15929
Type:
Small organic molecule
Emp. Form.:
C28H36N2OSi
Mol. Mass.:
444.6837
SMILES:
CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OC[Si](C)(C)c2ccc(cc2)C#N)c1
Structure:
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