Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50018556
Substrate
n/a
Meas. Tech.
ChEMBL_496613 (CHEMBL1003788)
IC50
>10000±n/a nM
Citation
 Bongartz, JP; Buntinx, M; Coesemans, E; Hermans, B; Lommen, GV; Wauwe, JV Synthesis and structure-activity relationship of benzetimide derivatives as human CXCR3 antagonists. Bioorg Med Chem Lett 18:5819-23 (2009) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50018556
Synonyms:
(+)-1'-benzyl-3-phenyl-3,4'-bipiperidine-2,6-dione | (+/-)-1'-benzyl-3-phenyl-3,4'-bipiperidine-2,6-dione | (-)-1'-benzyl-3-phenyl-3,4'-bipiperidine-2,6-dione | 1'-Benzyl-3-phenyl-[3,4']bipiperidinyl-2,6-dione | CHEMBL10272 | Dexetimide1'-Benzyl-3-phenyl-[3,4']bipiperidinyl-2,6-dione
Type:
Small organic molecule
Emp. Form.:
C23H26N2O2
Mol. Mass.:
362.4647
SMILES:
O=C1CCC(C2CCN(Cc3ccccc3)CC2)(C(=O)N1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: