Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50293184
Substrate
n/a
Meas. Tech.
ChEMBL_497215 (CHEMBL1003672)
Ki
165±n/a nM
Citation
 Letavic, MA; Keith, JM; Ly, KS; Bonaventure, P; Feinstein, MA; Lord, B; Miller, KL; Motley, ST; Nepomuceno, D; Sutton, SW; Carruthers, NI 2-Aryloxymethylmorpholine histamine H(3) antagonists. Bioorg Med Chem Lett 18:5796-9 (2009) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50293184
Synonyms:
4-ethyl-2-((4-(morpholinomethyl)phenoxy)methyl)morpholine | CHEMBL498201
Type:
Small organic molecule
Emp. Form.:
C18H28N2O3
Mol. Mass.:
320.4265
SMILES:
CCN1CCOC(COc2ccc(CN3CCOCC3)cc2)C1
Structure:
Search PDB for entries with ligand similarity: