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Target
Gamma-aminobutyric acid receptor subunit alpha-3
Ligand
BDBM50293263
Substrate
n/a
Meas. Tech.
ChEMBL_492500 (CHEMBL950413)
Ki
11±n/a nM
Citation
 Nilsson, J; Nielsen, EŘ; Liljefors, T; Nielsen, M; Sterner, O Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors. Bioorg Med Chem Lett 18:5713-6 (2009) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-3
Synonyms:
GABA A anti-Alpha3 | GABA A receptor alpha-3/beta-2/gamma-2 | GABA receptor alpha-3 subunit | GBRA3_RAT | Gabra-3 | Gabra3 | Gamma-aminobutyric acid receptor subunit alpha-3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55444.88
Organism:
RAT
Description:
GABA A Alpha3Beta2Gamma2 0 RAT::P20236
Residue:
493
Sequence:
MITTQMWHFYVTRVGLLLLISILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFMAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKTSTTFNIVGTTYPINLALDTEFSTISKAAAAPSASSTPTVIASPKTTYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
  
Inhibitor
Name:
BDBM50293263
Synonyms:
2-(5-benzyl-2-hydroxyphenyl)-6-methyl-4H-chromen-4-one | CHEMBL522061
Type:
Small organic molecule
Emp. Form.:
C23H18O3
Mol. Mass.:
342.3872
SMILES:
Cc1ccc2oc(cc(=O)c2c1)-c1cc(Cc2ccccc2)ccc1O
Structure:
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