Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-3
Ligand
BDBM50293264
Substrate
n/a
Meas. Tech.
ChEMBL_492500 (CHEMBL950413)
Ki
99±n/a nM
Citation
 Nilsson, J; Nielsen, EŘ; Liljefors, T; Nielsen, M; Sterner, O Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors. Bioorg Med Chem Lett 18:5713-6 (2009) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-3
Synonyms:
GABA A anti-Alpha3 | GABA A receptor alpha-3/beta-2/gamma-2 | GABA receptor alpha-3 subunit | GBRA3_RAT | Gabra-3 | Gabra3 | Gamma-aminobutyric acid receptor subunit alpha-3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55444.88
Organism:
RAT
Description:
GABA A Alpha3Beta2Gamma2 0 RAT::P20236
Residue:
493
Sequence:
MITTQMWHFYVTRVGLLLLISILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFMAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKTSTTFNIVGTTYPINLALDTEFSTISKAAAAPSASSTPTVIASPKTTYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
  
Inhibitor
Name:
BDBM50293264
Synonyms:
2-(5-bromo-2-hydroxyphenyl)-6-methylquinolin-4(1H)-one | CHEMBL452728
Type:
Small organic molecule
Emp. Form.:
C16H12BrNO2
Mol. Mass.:
330.176
SMILES:
Cc1ccc2nc(cc(O)c2c1)-c1cc(Br)ccc1O
Structure:
Search PDB for entries with ligand similarity: