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Target
Prostaglandin E synthase
Ligand
BDBM50294201
Substrate
n/a
Meas. Tech.
ChEMBL_571973 (CHEMBL1036476)
IC50
1800±n/a nM
Citation
 Liedtke, AJ; Keck, PR; Lehmann, F; Koeberle, A; Werz, O; Laufer, SA Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX). J Med Chem 52:4968-72 (2009) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50294201
Synonyms:
3-(6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)propanoic acid | CHEMBL550489
Type:
Small organic molecule
Emp. Form.:
C22H20ClNO2
Mol. Mass.:
365.853
SMILES:
OC(=O)CCc1c(c(c2CCCn12)-c1ccccc1)-c1ccc(Cl)cc1
Structure:
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