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Target
Prokineticin receptor 1
Ligand
BDBM50294597
Substrate
n/a
Meas. Tech.
ChEMBL_575799 (CHEMBL1057723)
IC50
>10000±n/a nM
Citation
 Ralbovsky, JL; Lisko, JG; Palmer, JM; Mabus, J; Chevalier, KM; Schulz, MJ; Dyatkin, AB; Miskowski, TA; Coats, SJ; Hornby, P; He, W Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation. Bioorg Med Chem Lett 19:2661-3 (2009) [PubMed]  Article 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM50294597
Synonyms:
1-(2-(5-(4-fluorobenzyl)-1-(4-nitrobenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine | CHEMBL562609
Type:
Small organic molecule
Emp. Form.:
C20H21FN8O4
Mol. Mass.:
456.4303
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#7]-c1nc(=O)n(-[#6]-c2ccc(F)cc2)c(=O)n1-[#6]-c1ccc(cc1)-[#7+](-[#8-])=O
Structure:
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