Reaction Details Report a problem with these data
Target
Prokineticin receptor 1
Ligand
BDBM50294602
Substrate
n/a
Meas. Tech.
ChEMBL_575799 (CHEMBL1057723)
IC50
1870±n/a nM
Citation
 Ralbovsky, JL; Lisko, JG; Palmer, JM; Mabus, J; Chevalier, KM; Schulz, MJ; Dyatkin, AB; Miskowski, TA; Coats, SJ; Hornby, P; He, W Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation. Bioorg Med Chem Lett 19:2661-3 (2009) [PubMed]  Article 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM50294602
Synonyms:
1-(2-(5-(4-chlorobenzyl)-1-(furan-3-yl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine | CHEMBL563890
Type:
Small organic molecule
Emp. Form.:
C17H18ClN7O3
Mol. Mass.:
403.823
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#7]-c1nc(=O)n(-[#6]-c2ccc(Cl)cc2)c(=O)n1-c1ccoc1
Structure:
Search PDB for entries with ligand similarity: