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Target
Oxysterols receptor LXR-alpha
Ligand
BDBM50294739
Substrate
n/a
Meas. Tech.
ChEMBL_576266 (CHEMBL1027818)
IC50
134000±n/a nM
Citation
 Hu, B; Unwalla, R; Collini, M; Quinet, E; Feingold, I; Goos-Nilsson, A; Wihelmsson, A; Nambi, P; Wrobel, J Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta. Bioorg Med Chem 17:3519-27 (2009) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50294739
Synonyms:
CHEMBL549892 | {3-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}-(1H-indol-7-ylmethyl)amine
Type:
Small organic molecule
Emp. Form.:
C32H24F3N3
Mol. Mass.:
507.5483
SMILES:
FC(F)(F)c1cccc2c(c(Cc3ccccc3)cnc12)-c1cccc(NCc2cccc3cc[nH]c23)c1
Structure:
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