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Target
NAD kinase
Ligand
BDBM50295366
Substrate
n/a
Meas. Tech.
ChEMBL_578493 (CHEMBL1063152)
IC50
500000±n/a nM
Citation
 Petrelli, R; Sham, YY; Chen, L; Felczak, K; Bennett, E; Wilson, D; Aldrich, C; Yu, JS; Cappellacci, L; Franchetti, P; Grifantini, M; Mazzola, F; Di Stefano, M; Magni, G; Pankiewicz, KW Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues. Bioorg Med Chem 17:5656-64 (2009) [PubMed]  Article 
Target
Name:
NAD kinase
Synonyms:
Inorganic polyphosphate/ATP-NAD kinase | NADK_MYCTU | ppnK
Type:
PROTEIN
Mol. Mass.:
32896.75
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_578493
Residue:
307
Sequence:
MTAHRSVLLVVHTGRDEATETARRVEKVLGDNKIALRVLSAEAVDRGSLHLAPDDMRAMGVEIEVVDADQHAADGCELVLVLGGDGTFLRAAELARNASIPVLGVNLGRIGFLAEAEAEAIDAVLEHVVAQDYRVEDRLTLDVVVRQGGRIVNRGWALNEVSLEKGPRLGVLGVVVEIDGRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVVPNNAHALFGRPMVTSPEATIAIEIEADGHDALVFCDGRREMLIPAGSRLEVTRCVTSVKWARLDSAPFTDRLVRKFRLPVTGWRGK
  
Inhibitor
Name:
BDBM50295366
Synonyms:
CHEMBL558497 | Di(2'-C-methyladenosine-5'-yl)disulfide
Type:
Small organic molecule
Emp. Form.:
C22H28N10O6S2
Mol. Mass.:
592.651
SMILES:
C[C@@]1(O)[C@H](O)[C@@H](CSSC[C@H]2O[C@@H](n3cnc4c(N)ncnc34)[C@](C)(O)[C@@H]2O)O[C@H]1n1cnc2c(N)ncnc12 |r|
Structure:
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