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Target
NAD kinase
Ligand
BDBM50295367
Substrate
n/a
Meas. Tech.
ChEMBL_578494 (CHEMBL1063153)
IC50
45000±n/a nM
Citation
 Petrelli, R; Sham, YY; Chen, L; Felczak, K; Bennett, E; Wilson, D; Aldrich, C; Yu, JS; Cappellacci, L; Franchetti, P; Grifantini, M; Mazzola, F; Di Stefano, M; Magni, G; Pankiewicz, KW Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues. Bioorg Med Chem 17:5656-64 (2009) [PubMed]  Article 
Target
Name:
NAD kinase
Synonyms:
NADK | NADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
49227.18
Organism:
Homo sapiens (Human)
Description:
ChEMBL_578494
Residue:
446
Sequence:
MEMEQEKMTMNKELSPDAAAYCCSACHGDETWSYNHPIRGRAKSRSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTIMHIQDPASQRLTWNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAIASDESFGAVKKKFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKELRGKKTAVHNGLGENGSQAAGLDMDVGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDPVSDWFESLAQCLHWNVRKKQAHFEEEEEEEEEG
  
Inhibitor
Name:
BDBM50295367
Synonyms:
CHEMBL538665 | Di(8-Phenyladenosine-5'-yl)disulfide
Type:
Small organic molecule
Emp. Form.:
C32H32N10O6S2
Mol. Mass.:
716.79
SMILES:
Nc1ncnc2n([C@@H]3O[C@H](CSSC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4c(nc5c(N)ncnc45)-c4ccccc4)[C@@H](O)[C@H]3O)c(nc12)-c1ccccc1 |r|
Structure:
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