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Target
Tyrosinase
Ligand
BDBM50296395
Substrate
n/a
Meas. Tech.
ChEMBL_580596 (CHEMBL1054042)
IC50
>250000±n/a nM
Citation
 Lee, KH; Ab Aziz, FH; Syahida, A; Abas, F; Shaari, K; Israf, DA; Lajis, NH Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities. Eur J Med Chem 44:3195-200 (2009) [PubMed]  Article 
Target
Name:
Tyrosinase
Synonyms:
LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | TYRO_HUMAN | Tumor rejection antigen AB
Type:
Protein
Mol. Mass.:
60388.08
Organism:
Homo sapiens (Human)
Description:
P14679
Residue:
529
Sequence:
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
  
Inhibitor
Name:
BDBM50296395
Synonyms:
2,6-Bis-(4-chloro-benzylidene)-cyclohexanone | 2,6-bis(4-chlorobenzylidene)cyclohexanone | CHEMBL474918
Type:
Small organic molecule
Emp. Form.:
C20H16Cl2O
Mol. Mass.:
343.246
SMILES:
Clc1ccc(\C=C2/CCC\C(=C/c3ccc(Cl)cc3)C2=O)cc1
Structure:
Search PDB for entries with ligand similarity: