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Target
Probable C-C chemokine receptor type 3
Ligand
BDBM50264212
Substrate
n/a
Meas. Tech.
ChEMBL_581443 (CHEMBL1055687)
IC50
1100±n/a nM
Citation
 Sato, I; Morihira, K; Inami, H; Kubota, H; Morokata, T; Suzuki, K; Ohno, K; Iura, Y; Nitta, A; Imaoka, T; Takahashi, T; Takeuchi, M; Ohta, M; Tsukamoto, S Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists. Bioorg Med Chem 17:5989-6002 (2009) [PubMed]  Article 
Target
Name:
Probable C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 | CC-CKR-3 | CCR-3 | CCR3_MOUSE | CD_antigen=CD193 | CKR3 | Ccr3 | Cmkbr1l2 | Cmkbr3 | MIP-1 alpha RL2 | Macrophage inflammatory protein 1-alpha receptor-like 2 | Probable C-C chemokine receptor type 3
Type:
PROTEIN
Mol. Mass.:
41791.57
Organism:
Mus musculus
Description:
ChEMBL_1445729
Residue:
359
Sequence:
MAFNTDEIKTVVESFETTPYEYEWAPPCEKVRIKELGSWLLPPLYSLVFIIGLLGNMMVVLILIKYRKLQIMTNIYLFNLAISDLLFLFTVPFWIHYVLWNEWGFGHYMCKMLSGFYYLALYSEIFFIILLTIDRYLAIVHAVFALRARTVTFATITSIITWGLAGLAALPEFIFHESQDSFGEFSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHKAIRLIFVVMIVFFIFWTPYNLVLLFSAFHSTFLETSCQQSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKHLRLFFHRNVAVYLGKYIPFLPGEKMERTSSVSPSTGEQEISVVF
  
Inhibitor
Name:
BDBM50264212
Synonyms:
CHEMBL519042 | N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-3-(piperidin-1-ylcarbonyl)isonicotinamide 1-oxide
Type:
Small organic molecule
Emp. Form.:
C30H33FN4O3
Mol. Mass.:
516.6064
SMILES:
[O-][n+]1ccc(C(=O)NC2C[C@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)c(c1)C(=O)N1CCCCC1 |r,TLB:16:15:8.9.14:11.12,7:8:15:11.12|
Structure:
Search PDB for entries with ligand similarity: