Reaction Details Report a problem with these data
Target
Acyl-CoA desaturase 1
Ligand
BDBM50298909
Substrate
n/a
Meas. Tech.
ChEMBL_588105 (CHEMBL1044831)
IC50
12±n/a nM
Citation
Koltun, DO; Zilbershtein, TM; Migulin, VA; Vasilevich, NI; Parkhill, EQ; Glushkov, AI; McGregor, MJ; Brunn, SA; Chu, N; Hao, J; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett 19:4070-4 (2009) [PubMed] Article
More Info.:
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1)
Type:
Enzyme
Mol. Mass.:
41485.97
Organism:
Rattus norvegicus (Rat)
Description:
P07308
Residue:
358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
Inhibitor
Name:
BDBM50298909
Synonyms:
CHEMBL573830 | N-(2-(6-(3,4-dichlorobenzylamino)-2,2-dimethyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)-2-hydroxyacetamide
Type:
Small organic molecule
Emp. Form.:
C21H23Cl2N3O4
Mol. Mass.:
452.331
SMILES:
CC1(C)Oc2ccc(NCc3ccc(Cl)c(Cl)c3)cc2N(CCNC(=O)CO)C1=O