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Target
Elongation of very long chain fatty acids protein 5
Ligand
BDBM50298968
Substrate
n/a
Meas. Tech.
ChEMBL_588230 (CHEMBL1043984)
IC50
>10000±n/a nM
Citation
 Sasaki, T; Nagase, T; Takahashi, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. Bioorg Med Chem 17:5639-47 (2009) [PubMed]  Article 
Target
Name:
Elongation of very long chain fatty acids protein 5
Synonyms:
ELOV5_HUMAN | ELOVL2 | ELOVL5
Type:
PROTEIN
Mol. Mass.:
35313.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_572243
Residue:
299
Sequence:
MEHFDASLSTYFKALLGPRDTRVKGWFLLDNYIPTFICSVIYLLIVWLGPKYMRNKQPFSCRGILVVYNLGLTLLSLYMFCELVTGVWEGKYNFFCQGTRTAGESDMKIIRVLWWYYFSKLIEFMDTFFFILRKNNHQITVLHVYHHASMLNIWWFVMNWVPCGHSYFGATLNSFIHVLMYSYYGLSSVPSMRPYLWWKKYITQGQLLQFVLTIIQTSCGVIWPCTFPLGWLYFQIGYMISLIALFTNFYIQTYNKKGASRRKDHLKDHQNGSMAAVNGHTNSFSPLENNVKPRKLRKD
  
Inhibitor
Name:
BDBM50298968
Synonyms:
(1R*,4S*,6R*)-(+/-)-2-[(1-Methyl-1H-imidazol-4-yl)sulfonyl]-N-[4-(propan-2-yloxy)phenyl]-2-azabicyclo[2.2.2]octane-6-carboxamide | CHEMBL578249
Type:
Small organic molecule
Emp. Form.:
C21H28N4O4S
Mol. Mass.:
432.536
SMILES:
CC(C)Oc1ccc(NC(=O)[C@@H]2C[C@@H]3CC[C@@H]2N(C3)S(=O)(=O)c2cn(C)cn2)cc1 |r,TLB:9:11:18.17:14.15,THB:19:17:12.11:14.15|
Structure:
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